Orbitrap Eclipse Tribrid MS System

Go beyond today’s discovery

When complex analytical questions require a definitive answer, you need a powerful and versatile solution that will allow you to accurately resolve subtle differences, distinguish the right answer from many wrong ones, and avoid costly dead ends.

Introducing the Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ mass spectrometer, our newest generation instrument designed with your most difficult analytical challenges in mind. With enhanced performance and usability, the Orbitrap Eclipse Tribrid mass spectrometer makes it easy to produce the high-quality data required to drive the right decisions, while expanding the breadth of your work and pushing your science beyond today’s discovery.

The Orbitrap Eclipse Tribrid mass spectrometer amplifies the power and versatility of the innovative Thermo Scientific™ Tribrid™ design by incorporating the latest inventions in ion transmission and control, extended m/z range, and real-time decision making.

These new functionalities provide ground-breaking gains in sensitivity, selectivity and versatility, making the instrument ideally suited for obtaining comprehensive results from proteomics, structural biology, small-molecule, and biopharmaceutical characterization experiments.

1. High-Capacity Transfer Tube (HCTT) - Increases ion flux into the mass spectrometer
2. Electrodynamic Ion Funnel - Focuses ions after HCTT
3. EASY-IC/ETD/PTCR Ion Source - Based on Townsend discharge; reliable and easy to use
4. Advanced Active Ion Beam Guide - Prevents contaminants from entering the mass resolving quadrupole
5. QR5 Segmented Quadrupole Mass Filter with Hyperbolic Surfaces - Improves sensitivity with 0.4 m/z precursor isolation width
6. Ultra-High-Field Orbitrap Mass Analyzer - Offers resolution >500,000 FWHM (optionally > 1,000, 000 FWHM) and MSn acquisition rate up to 40 Hz; enables TurboTMT and HMRn
7. Ultra-High Vacuum (UHV) Manifold - Reduces pressure in the UHV region; improves ion detection in the Orbitrap mass analyzer
8. Ion-Routing Multipole - Enable higher acquisition rates; performs HCD at any MSn stage; allows variable pressure (0.5–20 mTorr) for superior top-down performance
9. Real-Time Search - Provides on-the-fly peptide identification, increasing depth and accuracy of TMT quantitation
10. Modified Dual-Pressure Linear Ion Trap - Enables MSn for ion detection in both ion trap and Orbitrap mass analyzers; sensitive mass analysis for multiple fragmentation modes: CID, HCD, ETD/EThcD/ETciD and UVPD; and precursor ion isolation for HMRn. The extended front section of the high-pressure cell improves control over ETD and PTCR reactions.