MAbPac & ProPac Columns

Columns designed for high-resolution accurate mass analysis of monoclonal antibodies (mAbs), antibody drug
conjugates (ADCs) and other proteins using reversed-phase HPLC and LCMS for high-resolution separations.

Compatible with organic solvent used in HPLC and MS under RP conditions

• Resin is based on a hydrophobic supermacroporous 4µm polymer particles
• Stable at extreme pH (0 to 14) and high temperature (up to 110 °C)

Efficient with low carry over

• 1,500Å large pore size polymeric resin
• Efficient separation of protein molecules with very low carry over

Designed for reversed-phase biomolecule LC and LC/MS separations

• Superior resolution power for monoclonal antibodies and related substances
• High efficiency with low carry-over
• Excellent MS compatibility
• Wide operating pH range: 0 to 14
• High temperature stability: up to 110°C
• High throughput

ProPac columns are designed to address the regulatory requirements for biopharmaceutical characterization. The reproducible resin chemistry and manufacturing processes eliminate column variability as a concern in methods development and data analysis.

ProPac columns are available with weak or strong anion-exchange or cation-exchange resins packed in 2-, 4-, 9-, and 22-mm i.d. formats. The selectivity differences between the various resin types provide flexibility in maximizing the resolution of closely related proteins.