ZipChip Interface

The 908 Devices™ ZipChip™ system coupled to the Thermo Scientific™ Q Exactive™ hybrid quadrupole-Orbitrap™ and other compatible mass  spectrometer platforms can characterize a wide range of bio-analytes via  unique microfluidic capillary electrophoresis (CE) separation and high-resolution accurate-mass (HRAM) mass spectrometry identification. This  exceptionally fast, sensitive, and accurate CE/ESI-MS workflow complements 
LC-MS technology to address analytical challenges in biopharma.

The ZipChip system and compatible MS platforms can quickly analyze intact  mAbs in native, partially denatured, and fully denatured conditions to support  characterization of biotherapeutics under a diverse range of  conditions.  Heterogeneous ADCs can be successfully characterized in under 3 minutes by utilizing a ZipChip system and Q Exactive MS workflow with Thermo Scientific™ BioPharma Finder™ software. Fast, sensitive, and accurate antibody subunit  analysis can be accomplished by the ZipChip system and Q Exactive Plus,  Q Exactive HF, and/or Q Exactive HF-X MS BioPharma option platforms.  The combination of the ZipChip system sample separation, Q Exactive MS  produced HRAM MS and MS/MS spectra, and BioPharma Finder software  enables fast and accurate peptide identification.