Introducing the next-generation Orbitrap LCMS Excedion Pro

Thermo Scientific Orbitrap Excedion Pro Mass Spectrometer

Elevating discovery with unmatched sensitivity, speed, and versatility

The Excedion Pro is Thermo Fisher flagship benchtop hybrid Orbitrap LC‑MS system, offering breakthrough performance for advanced research applications. Ideal for scientists in proteomics, biopharma, metabolomics, and structural biology, it surpasses its predecessor (Exploris 480) with superior sensitivity, dynamic range, and scanning speed.

Key Features

High-resolution Orbitrap analyzer with extended mass range up to m/z 12,000 and resolving power up to 480,000 FWHM at m/z 200
EThcD fragmentation via combined ETD and HCD for in-depth peptide/protein sequencing and PTM localization
Fast MS2 scan rates up to 70 Hz with enhanced dynamic range (eDR), enabling detection of low-abundance species.
OptaMax Plus and OptiSpray ion sources for stable nano‑ and micro‑flow performance; FAIMS Pro Duo compatibility boosts selectivity.
Electrodynamic ion funnel and bent C‑trap, optimizing transmission of labile ions for improved sensitivity.
Single dry roughing pump design reduces energy consumption by 30%, lowers noise/heat, and offers five-year pump maintenance.

Ideal Applications

Biopharma: Complete characterization of biotherapeutics (e.g. monoclonal antibodies, bispecifics), PTMs, structural isoforms. Suitable for top/middle/bottom-up workflows with confident impurity detection.
Proteomics: Deep sequencing with high coverage using hybrid‑DIA, PTM and immunopeptidomics workflows enabled by EThcD and eDR.
Metabolomics / Lipidomics: Enhanced depth of coverage in untargeted workflows, preserving labile metabolites with minimized fragmentation.
Structural Biology / HDX‑MS: High-throughput, high-coverage peptide mapping and dynamics analysis. >99% sequence coverage in minutes.

Why Choose Excedion Pro?

Revolutionary sensitivity and dynamic range for detecting trace biomolecules.
Rapid, high-resolution scans-up to 70 Hz MS2 and deep dynamic range acquisition.
Advanced fragmentation chemistry (EThcD) for confident PTM and isoform mapping.
Optimized workflow compatibility: nano‑, micro‑, and standard flow with FAIMS options.
Operational efficiency: compact footprint, single pump operation, and reduced energy footprint.

Summary

The Thermo Scientific Orbitrap Excedion Pro MS is the ultimate hybrid LC‑MS platform - delivering exceptional sensitivity, speed, and robustness for the most demanding omics and biopharma workflows. Seamlessly integrated into the Thermo Fisher ecosystem, ideal for cutting-edge labs striving for discovery and accuracy.

More information HERE